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Wysłany: Pią 3:00, 20 Kwi 2007
Temat postu: Lorazepam and fluxoetine resourse
Diazepam is here best administered once daily to tackle this aspect of dependence
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In the treatment of status epilepticus due to acute reversible metabolic derangement (e
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GABA inhibits activity in many of the nerves of the brain, and it is thought that this excessive activity is what causes anxiety or other psychological disorders
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Get up slowly from a sitting or reclining position, and be careful on stairs
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Lorazepam has fewer interactions with other medications than most of the other benzodiazepines
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use: Aspirate the desired amount of lorazepam injection into t
he syringe, then slowly aspirate the desired volume of diluent
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Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand
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Pain at the injection site, a sensation of burning, and redness in the same area have been reported after i
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Proper resuscitation equipment should be available
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Lorazepam and other benzodiazepines act by enhancing the effects of gamma-aminobutyric acid (GABA)
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Suddenly stopping therapy after a few months of daily therapy may be associated with a feeling of loss of self-worth, agitation, and insomnia
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As your body adjusts to the medication, these side effects should diminish or disappear
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Giving a similar amount of lorazepam intravenously will result in a higher peak serum lorazepam level, initially consisting mainly of unmetabolised, active lorazepam
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The dose is reduced gradually over a period of months or years, depending on prior dose and duration of use
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As is true of other similar CNS acting drugs, patients receiving injectable lorazepam should not operate machinery or engage in hazardous occupations or drive a motor vehicle for a period of 24 to 48 hours
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Tolerance may develop with long-term or excessive use, making the drug less effective
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Lorazepam is therefore replacing diazepam as an intravenous drug of choice in status epilepticus
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Avoid alcohol while taking lorazepam
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Lorazepam and other benzodiazepines have been associated with fetal damage, including congenital malformations, when taken by pregnant women in their first
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Be sure to tell your doctor if you are pregnant
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The most commonly noted side effects associated with lorazepam are sedation (which is reported in approximately 1 in 6 people), dizziness (1 in 15), weakness, and unsteadiness
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Bitter taste in the mouth, constipation, diarrhea, dizziness, drowsiness (after a night's sleep), dry mouth, fatigue, flushing, headache, heartburn, excessive salivation, loss of appetite, nausea, nervousness, sweating, or vomiting
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, when added to other medications) to prevent nausea and vomiting in patients receiving cancer chemotherapy Lorazepam and all benzodiazepines, interact with other medications and drugs tha
t slow the brain's processes such as alcohol, barbiturates, and narcotics
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There have been cases of marked sedation when lorazepam was given to patients taking the tranquilizer loxapine (Loxitane); it is unclear if there is a drug interaction at all, but concern is warranted
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Those with preexisting substance abuse disorders or addictive personalities are more likely to abuse medications such as lorazepam, and care should be taken if prescribing it on an outpatient basis
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6% in the stool
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05 mg/kg is given and when narcotic analgesics are used concomitantly with the recommended dose
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[1] Lorazepam is rapidly and nearly completely absorbed after any mode of administration (oral, sublingual, intramuscular [i
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Hypertension and hypotension have occasionally been observed after injectable lorazepam
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Ativan (Lorazepam) is an anti-anxiety agent (benzodiazepines,mild tranquilizer) used for the relief of anxiety, agitation and irritability, to relieve insomnia, to calm people with mania / schizophrenia and intravenously as a sedative and for nervous tension or to relieve anxiety prior to surgery
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This contrasts with diazepam, which is highly lipid soluble and so more extensively distributed in the body
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The British National Formulary equates the effects of 1 mg of lorazepam to the effects of 10mg diazepam
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Your doctor may recommend a gradual reduction in dose It is a nearly white powder almost insoluble in water
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Lorazepam is 85% bound to plasma proteins
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Each Ativan (lorazepam) tablet, to be taken orally, contains 0
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Lorazepam is used for the management of anxiety disorders, the short-term relief of the symptoms of anxiety or anxiety associated with depression
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, lorazepam injection, undiluted, should be injected
deep into a muscle mass
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Lorazepam concentrate (liquid) comes with a specially marked drop
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Lorazepam's inactive metabolite is another advantage over diazepam in this setting
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Coming off lorazepam is more realistically achieved by, first, gradually changing over to an equivalent dose of diazepam and, secondly, stabilising the patient on diazepam before contemplating dose reductions
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When lorazepam injection is used i
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Peak concentrations are reached in 60 to 90 minutes after i
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use, lorazepam injection should be diluted with an equal amount of compatible diluent (see Dosage)
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Ativan (Lorazepam) may also be used to help in the prevention of severe alcohol withdraw symptoms (Delirium Tremens, or DTs), to treat amnesia, or in patients who are undergoing chemotherapy and have severe vomiting
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When scopolamine is used concomitantly with injectable lorazepam, an increased incidence of sedation, hallucinations and irrational behaviour has been observed
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In the case of an oral overdose, if vomiting has not occurred spontaneously and the patient is fully awake, it may be induced with 20 to 30 mL of ipecac syrup USP
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Lorazepam injection is compatible for dilution purposes with the following solutions: Sterile Water for Injection, USP, Sodium Chloride Injection, USP, 5% Dextrose Injection, USP, Bacteriostatic Sodium Chloride Injection, USP with benzyl alcohol, Bacteriostatic Water for Injection, USP with parabens, Bacteriostatic Water for Injection, USP with benzyl alcohol
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In patients with normal liver function the serum half-life of lorazepam is 11 to 18 hours, so it is unsuitable for once-daily administration and therefore usually given as 2 to 4 daily doses if administered regularly
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Tell your doctor about all medicines that you are taking, and do not take any medicine without first talking to your doctor
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This stabilisation period is important since lorazepam levels (and effects) fluctuate more than those of diazepam: anxiety symptoms are more noticeable when lorazepam wears off and symptom relief more drastic when taking another dose, which may reinforce psychological dependence
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Because of lorazepam's relative low lipid solubility, its distribution in the body is mainly the vascular compartment
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In addition, osmotic diuretics such as mannitol may be effective as adjunctive measures
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Resuscitative equipment for ventilatory support should be readily available
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Impairment of performance may per
sist for greater intervals because of extremes of age, concomitant use of other drugs, stress of surgery or the general condition of the patient
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Lorazepam is habit forming
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fluids and electrolytes may accelerate elimination of benzodiazepines from the body
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Several studies have suggested an increased risk of congenital malformations associated with the use of the benzodiazepines, chlordiazepoxide and diazepam, and meprobamate, during the first trimester of pregnancy
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There is no evidence to support the use of lorazepam injection in coma, shock o
r acute alcohol intoxication at this time
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Immediately mix contents thoroughly by gently inverting the syringe repeatedly until a homogenous solution results
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When properly diluted the drug may be injected directly into the vein or into the tubing of an existing i
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If lorazepam is to be combined with other drugs acting on the CNS, careful consideration should be given to the pharmacology of the agents to be employed because of the possible potentiation of drug effects
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Lorazepam is an antianxiety medication in the benzodiazepine family, the same family that includes diazepam (Valium), alprazolam (Xanax), clonazepam (Klonopin), flurazepam (Dalmane), and others
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As with other anxiolytic-sedative drugs, lorazepam should not be used in patients with nonpathological anxiety
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In women, blood levels obtained from umbilical cord blood indicate placental transfer of lorazepam and lorazepam glucuronide
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Lorazepam may be safer than many other benzodiazepines in patients with impaired liver function because it does not require hepatic oxidation, which means that, similar to oxazepam, it is less likely to accumulate to an extent where it causes adverse reactions
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Lorazepam injectable can be used with atropine sulfate, narcotic analgesics, other parenterally used analgesics, commonly used anesthetics and muscle relaxants
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Lorazepam can be habit-forming
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Therefore, patients should be warned against engaging in hazardous activities requiring mental alertness and motor coordination, such as operating dangerous machinery or driving motor vehicles
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use, lorazepam injection must be diluted with an equal volume of compatible solution
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Parenteral drug products
should be inspected visually for particulate matter and discoloration prior to administrati
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Addiction is not a unique problem to lorazepam but for the reasons given above lorazepam is best used short-term to minimise this risk
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The inactive ingredients present are lactose monohydrate, magnesium stearate, microcrystalline cellulose, and polacrilin potassium
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Also, lorazepam is thought to bind more strongly to GABA receptors
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This drug can pass into the breast milk and cause drowsiness, slowed heartbeat, and breathing difficulties in the nursing infant
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These events have occurred with dyspnea as the only preceding symptom
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This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors
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Upon the appearance of rash or of other allergic phenomena for which an alternative etiology cannot be identified, fluoxetine should be discontinued
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In neither patient was there an unequivocal diagnosis, but one was considered to have a leukocytoclastic vasculitis, and the other severe desquamation that was considered variously to be a vasculitis or erythema multiforme
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Fluoxetine does not have MAO activity
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Prozac Weekly capsules, a delayed-release formulation, contain enteric-coated pellets of fluoxetine hydrochloride equivalent to 90 mg (291 ľmol) of fluoxetine
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There may be other drugs not listed that can affect fluoxetine
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The Pulvules also contain starch, gelatin, silicone, titanium dioxide, iron oxide, and other inactive ingredients
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They can add to sleepiness caused by fluoxetine
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Fluoxetine is also available without a brand name, ie as the generic medicine
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Do not take extra medicine to make up the missed dose
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While you are taking fluoxetine you will need to be monitored for worsening symptoms of depression and/or suicidal thoughts during the first weeks of treatment, or whenever your dose is changed
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You must wait at least 14 days after stopping an MAOI before you can take fluoxetine
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Fluoxetine (Prozac) capsule, tablet, and liquid are usually taken once a day in the morning or twice a day, in the morning and at noon
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There have been reports of serious, sometimes fatal, reactions (including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital signs, and mental status changes that include extreme agitation progressing to delirium and coma) in patients receiving fluoxetine in combination with a MAO inhibitor and in patients who have recently discontinued fluoxetine and then started on a MAO inhibitor
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Fluoxetine hydrochloride is a wh
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Fluoxetine may also be used for purposes other than those listed in this medication guide
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Most patients improved promptly with discontinuation of fluoxetine and/or adjunctive treatment with antihistamines or steroids, and all patients experiencing these events were reported to recover completely
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As is true with many other types of medication when taken concurrently by patients with diabetes, insulin and/or oral hypoglycemic dosage may need to be adjusted when therapy with fluoxetine is instituted or discontinued
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Life-threatening interactions can occur in combination with MAO inhibitors, such as na
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Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand
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Do not use this medication without telling your doctor if you are breast-feeding a baby
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Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine
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Clinical experience with fluoxetine in patients with concomitant systemic illness is limited and it should be used cautiously in such patients, especially those with diseases or conditions that could affect metabolism or hemodynamic responses
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However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy
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A special MedGuide will be given to you by the pharmacist with each prescription and refill
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Patients with these diagnoses were systematically excluded from premarketing clinical studies
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The half-life of fluoxetine after a single dose is 2 days (range 1 to 4 days) and after multiple dosing 4 days (range 2 to 7 days)
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FLUOXETINE (ProzacŽ) belongs to a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs)
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