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PlavixMan
Wysłany: Pią 20:25, 20 Kwi 2007
Temat postu: Plavix Best resourse
These events are known as atherothrombotic events
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Cardiovascular disorders: Cardiac failure
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Plavix is used to prevent blood clots after a recent heart attack or stroke, and in people with certain disorders of the heart or blood vessels
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The following are some of the side effects that are known to be associated with this medicine
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Skin and appendage disorders: Bullous eruption, rash erythematous, rash maculopapular, urticaria
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5% of patients receiving Plavix (clopidogrel bisulfate) in the controlled clinical trials are listed below regardless of relationship to Plavix
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Do not take the medication in larger amounts, or take it for longer than recommended by your doctor
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By which I mean, not like the one that upheld Ariad's patent
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Coadministration of heparin had no effect on inhibition of platelet aggregation induced by Plavix
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Plavix keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions
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White cell and reticuloendothelial system disorders: Agranulocytosis, granulocytopenia, leukemia, leukopenia, neutropenia
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The incidence of fatal bleeding (0
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Psychiatric disorders: Anxiety, Insomnia
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In patients receiving aspirin, the corresponding rates were 2
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Gastrointestinal system disorders: Peptic, gastric or duodenal ulcer, gastritis, gastric ulcer perforated, gastritis hemorrhagic, upper GI ulcer hemorrhagic
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Do not use this medication without telling your doctor if you are breast-feeding a baby
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I'm a little sceptical of the size
of that effect - it's not unheard of for companies to unload other types of bad news under a convenient banner, given the chance - but there's no doubt that it's been a nasty experience
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NSAIDs include ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others
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Central and peripheral nervous system disorders: Cramps legs, Hypoaesthesia, Neuralgia, Paraesthesia, Vertigo
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For my part, I'd as soon see the generic companies go ahead and challenge the patent-holding ones, as long as the decisions are made in a competent legal venue
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) Other Concomitant Therapy: No clinically significant pharmacodynamic interactions were observed when Plavix was coadministered with atenolol, nifedipine, or both atenolol and nifedipine
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Last week, a judge issued an injunction against further sales by Apotex in the U
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These could be signs of bleeding in your digestive tract
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Your doctor may want to take a blood sample to check there are no problems with the number of blood cells in your blood
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Take this medication exactly as it was prescribed for you
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Clopidogrel works by preventing
a natural substance called ADP from binding to its receptors on platelets
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At high concentrations in vitro, clopidogrel inhibits P450 (2C9)
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NSAIDs include ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others
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To help you remember to take clopidogrel, take it around the same time every day
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8% versus 0
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7% and 1
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Hemorrhagic: In CAPRIE patients receiving Plavix, gastrointestinal hemorrhage occurred at a rate of 2
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Respiratory system disorders: Hemothorax
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Tell your doctor if you are pregnant or plan to become pregnant during treatment
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Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand
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No additional clinically relevant events to those observed in CAPRIE with a frequency ? 2
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4% for Plavix compared to 0
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You may need to stop using the medicine for at least 5 days before having surgery, to prevent excessive bleeding
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Do not miss any scheduled visits to your doctor
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ADP is one of the chemicals in the body that cause platelets to clump together and start the process of blood clotting
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Atherosclerosis is a build up of cholesterol and fat cells that narrows the blood vessels and makes their interiors rough and bumpy
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Blood clots and blockages mainly result from a build up of atherosclerosis on the inside of blood vessels
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However, you should tell your doctor promptly if you experience any unexplained bruising or unusual bleeding (eg bleeding from
an unusual site or that takes a very long time to stop), particularly if also accompanied by a fever, signs of infections, extreme tiredness or feeling generally unwell
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1%), and fatal bleeding (0
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In the last installment, Canadian generic company Apotex had snookered (a completely accurate description) Bristol-Meyers Squibb and Sanofi/Aventis into an ill-advised agreement that ended up destroying the drug's patent protection
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4% Plavix + aspirin; 5
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Plavix and aspirin have been administered together for up to one year
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Gastrointestinal system disorders: Constipation, Vomiting
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Reproductive disorders, female: Menorrhagia
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Aspirin: Aspirin did not modify the clopidogrel-mediated inhibition of ADP-induced platelet aggregation
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The pharmacokinetics of digoxin or theophylline were not modified by the coadministration of Plavix (clopidogrel bisulfate)
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Platelet, bleeding and clotting disorders: hemarthrosis, hematuria, hemoptysis, hemorrhage intracranial, hemorrhage retroperitoneal, hemorrhage of operative wound, ocular hemorrhage, pulmonary hemorrhage, purpura allergic, thrombocytopenia
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Cardiovascular disorders: Edema generalized
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1%, respectively
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Caution should be used when any of these drugs is coadministered with Plavix
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No legal bills can compare with the hit they've taken over generic Plavix
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It may take longer than normal for you to stop bleeding, for example if you accidentally cut yourself, while you are taking this medicine
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But they're clearly unhappy about the situation
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Plavix potentiated the effect of aspirin on collagen-induced platelet aggregation
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COMMIT collected only limited safety data
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That's not even going to begin until early next year, and you can be sure that BMS and S-A are going to drag it out as much as possible
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You may also have bleeding on the inside of your body, such as in your stomach or intestines
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Stor Plavix at room temperature away from moisture and heat
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Clopidogrel comes as a tablet to take by mouth
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Avoid drinking alcohol while taking Plavix
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Plavix tablets contain the active ingredient clopidogrel hydrogen sulphate, which is a type of medicine called an antiplatelet (sometimes referred to as a 'blood-thinning' medicine)
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In general, the incidence of these events was similar to that in patients receiving aspirin (in CAPRIE) or placebo + aspirin (in the other clinical trials)
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You may also have bleeding on the inside of your body, such as in your stomach or intestines
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Other adverse experiences of potential importance occurring in 1% to 2
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Similarly, people who have narrowed arteries in their extremities, eg legs, (peripheral arterial disease) are also at risk of blood clots
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Plavix can be taken with or without food
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Body as a Whole-general disorders: Asthenia, Fever, Hernia
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It is not known whether Plavix passes into breast milk or if it could harm a nursing baby
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At high concentrations in vitro, clopidogrel inhibits P450 (2C9)
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It stops blood cells called platelets from clumping together and forming blood clot
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Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack, unstable angina), recent stroke, or blood circulation disease (peripheral vascular disease)
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The incidence of intracranial hemorrhage was 0
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Take clopidogrel exactly as directed
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Alcohol may increase your risk of bleeding in your stomach or intestines
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3% versus 1
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Stor Plavix at room temperature away from moisture and heat
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5% versus 0
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The following are some of the side effects that are known to be associated with this medicine
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Red blood cell disorders: Anemia aplastic, anemia hypochromic
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1%), and fatal bleeding (0
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Aspirin: Aspirin did not modify the clopidogrel-mediated inhibition of ADP-induced platelet aggregation
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No legal bills can compare with the hit they've taken over generic Plavix
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Autonomic Nervous System Disorders: Syncope, Palpitation
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Use extra caution to avoid cuts when brushing your teeth or shaving
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Psychiatric disorders: Anxiety, Insomnia
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Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe
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Continue to take clopidogrel even if you feel well
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In the last installment, Canadian generic company Apotex had snookered (a completely accurate description) Bristol-Meyers Squibb and Sanofi/Aventis into an ill-advised agreement that ended up destroying the drug's patent protection
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Accordingly, Plavix may interfere with the metabolism of phenytoin, tamoxifen, tolbutamide, warfarin, torsemide, fluvastatin, and many non-steroidal anti-inflammatory agents, but there are no data with which to predict the magnitude of these interactions
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COMMIT collected only limited safety data
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Do not miss any scheduled visits to your doctor
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2%), were the same in both groups
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Contact your doctor or seek emergency medical attention if you have bleeding that will not stop
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For my part, I'd as soon see the generic compani
es go ahead and challenge the patent-holding ones, as long as the decisions are made in a competent legal venue
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Call your doctor at once if you have black or bloody stools, or if you cough up blood or vomit that looks like coffee grounds
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While you are taking Plavix, do not take aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) without your doctors advice
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Vision disorders: Cataract, Conjunctivitis
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To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis
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Reproductive disorders, female: Menorrhagia
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until the patent infringement trial is completed
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White cell and reticuloendothelial system disorders: Agranulocytosis, granulocytopenia, leukemia, leukopenia, neutropenia
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Take this medication exactly as it was prescribed for you
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8% versus 0
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Plavix is used to prevent blood clots after a recent heart attack or stroke, and in people with certain disorders of the heart or blood vessels
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When taking PLAVIX alone or with some medicines including aspirin, the risk of bleeding may increase
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You may need to stop using the medicine for at least 5 days before having surgery, to prevent excessive bleeding
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Blood clots and blockages mainly result from a build up of atherosclerosis on the inside of blood vessels
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To minimize this risk, talk to your doctor before taking aspirin or other medicines with PLAVIX
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The clinically important adverse events observed in CAPRIE, CURE, CLARITY and COMMIT are discussed below
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The incidence of intracranial hemorrhage (0
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In CLARITY, the incidence of major bleeding (defined as intracranial bleeding or bleeding associated with a fall in hemoglobin > 5 g/dL) was similar between groups (1
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It is usually taken once a day with or without food
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There was no excess in major bleeds within seven days after coronary bypass graft surgery in patients who stopped therapy more than five days prior to surgery (event rate 4
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Follow the directions on your prescription label
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Metabolic and nutritional disorders: Gout, hyperuricemia, non-protein nitrogen (NPN) increased
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ADP is one of the chemicals in the body that cause platelets to clump together and start the process of blood clotting
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Clopidogrel is used to prevent blood clots forming within blood vessels, and therefore reduce the risk of further atherothrombotic events in these groups of people
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Plavix potentiated the effect of aspirin on collagen-induced platelet aggregation
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Cardiovascular disorders: Cardiac failure
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Central and peripheral nervous system disorders: Cramps legs, Hypoaesthesia, Neuralgia, Paraesthesia, Vertigo
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